Effet anti - Candida albicans d'un extrait fongique formulé

Abstract

In this work, the antifungal and anti-inflammatory activities of a fungal extract obtained through solid-state fermentation using wheat bran as a substrate were prepared and evaluated. The results clearly showed that the extract possesses good antifungal activity but lacks anti-inflammatory properties. By comparing the efficacy of an ointment prepared from this extract with a commercial ointment (Econazole 1%), the results revealed no significant disparity between the two formulations. This finding confirms the potential of relying on a biologically derived treatment rather than a chemical one, providing a natural alternative that is equally effective in combating fungal infections. Gas chromatography-mass spectrometry (GC/MS) analysis was crucial in understanding the chemical and biological properties of the studied extract. This analysis provided detailed information on the chemical composition of the fungal extract, allowing for a better understanding of the underlying mechanisms of its biological activity. The compound 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, also known as kojic acid, which was predominant in this analysis (24%), is valued for its antifungal, antibacterial, and antioxidant properties. It protects cells from damage caused by free radicals. In the field of cosmetics, kojic acid lightens the skin by inhibiting melanin production, thereby reducing pigmentation spots. It is also used in food preservation and the textile industry, making it a versatile and essential compound in various fields.