Formulation optimisation et caractérisation d'une crème réparatrice de la peau a base des plantes médicinales

Abstract

The objective of this work is the formulation of a cream based on extracts obtained by two methods (maceration and hydrodistillation) for parapharmaceutical use. Two plants were studied, namely: blue cardoncell (Carthamus caeruleus L.) and Cypress (Cupressus semprevirens L.). The work is divided into four parts. The first focused on the optimization of maceration by Box Behnken plan and extraction by maceration and hydrodistillation. The second on the study of the cytotoxicity and the antimicrobial, antifungal, and antioxidant activity of the different extracts and essential oils (HEs). Finally, the third and fourth parts focused on the development of creams, their characterization as well as the study of the antiburn and healing activity In vivo. The results show that the prepared cream has very high antioxidant, antimicrobial, anti-burn and healing potential compared to standards.