Browsing by Author "Boushaba, Rihab"

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Comparaison entre quelques antibiotiques princeps et génériques commercialisés en Algérie via les tests de l’antibiogramme, l’uniformité de masse et la friabilité
(Université constantine 3 Salah boubnider, Faculté génie des procédés, 2020) El hadef el okki, Meroua; Chebouki, Amira; Boushaba, Rihab
The inferior quality of generic antibiotics compared to the branded ones may contribute to the problem of AMR according to some studies. The aim of this work is to carry out a comparative study of the antibacterial potency and technological properties of ten antibiotics that belong to three antibiotics families marketed in Algeria. The following families are represented: aminopenicillins (one branded and three generics), macrolides (one branded and two generics) and second generation cephalosporins (one branded and two generics). Our work also includes a survey of health professionals in the Constantine region to assess their perceptions about the use of antibiotics in health care facilities and the extent of antibiotic resistance. Our results indicate that the 190 health professionals surveyed are fully aware of the AMR problem and the irrational use of antibiotics. A significant proportion (62.1%) recognize that there is a difference in quality between branded and generic antibiotics. The disc diffusion technique revealed that the diameters of the inhibition zones of tree generic antibiotics are statistically different (by 19.67%, 29.5% and 51.52 %) than their branded homologs (2 belonging to the amino-penicillin family and 1 to the macrolide family, all tested on the reference strain E. coli). No differences were found for the other generic antibiotics that belong to these families as well as for those belonging to the second-generation cephalosporin family on all reference strains tested (E. coli, P. aeruginosa and S. epidermidis). The quality control tests carried out (mass uniformity and friability) also revealed that all the antibiotics analysed were compliant. Given that the regulatory approval of generic antibiotics is based on their conformity with respect to pharmaco-technical standards (especially similarity of the dissolution profile with that of the branded counterpart), our results indicate that this may not be enough to guarantee the antimicrobial potency equivalence between generic antibiotics and their branded counterparts. This may contribute to the phenomenon of AMR
Étude comparative des profils de dissolution des médicaments commercialisés en algerie amlor et amlodipine
(Université constantine 3 Salah boubnider, Faculté génie des procédés, 2022) Ghiat, Racha; Besbas, Shaima; Boushaba, Rihab
Résumé Le test de dissolution est un outil important pour l’évaluation de la qualité des médicaments. L’objectif de notre travail est d’analyser les cinétiques de dissolution de deux médicaments, le princeps (Amlor 5 mg) et son générique (Amlodipine 5 mg). La méthode adoptée se base sur une étude comparative des différents profils de dissolution de ces médicaments, en prenant en considération l’effet du pH du milieu de dissolution, de la vitesse d’agitation et de la formulation du médicament. Les résultats de l’étude indiquent que les facteurs ; pH du milieu, vitesse d’agitation et la formulation influencent la cinétique de dissolution. L’étude recommande d’approfondir la recherche sur les excipients composants ces deux médicaments.
Production de bioéthanol et substances bioactives par fermentation en milieu solide
(Université Constantine 3 Salah Boubnider, Faculté de génie des procédés, 2023) Denech, Mohamed Chaker; Khebbab, Rami Aymen; Latreche, Mohamed El Mehdi Mouatez; Boushaba, Rihab
L'objectif de cette étude est d’explorer les potentialités de la fermentation en milieu solide(FMS) pour la production de bioactifs et bioéthanol selon une démarche de bioraffinerie. Le substrat utilisé dans ce travail est la pelure de betterave (Beta vulgaris) qui est un aliment connu pour ses multiples bienfaits pour la santé. Des essais de FMS par la levure Saccharomyces cerevisiae ont été réalisés en variant les facteurs suivants : la taille des particules du substrat broyé, la source d’azote et la concentration de l’inoculum. Les paramètres suivis étaient: le pH, les sucres totaux, la biomasse, les groupes phénoliques totaux et l’activité antioxydantes des extraits de fermentation. Les extraits de fermentation ont aussi été analysés par FTIR pour la mise en évidence du bioéthanol.
Validation d'un procédé de fabrication de comprimés pelliculés : application de l’analyse des risques et des cartes de contrôle
(Université constantine 3 Salah boubnider, Faculté génie des procédés, 2020) Boudemagh, Ikram; Makhelfi, Imane; Boushaba, Rihab
The purpose of validation is to provide documented proof that a process has been developed according to the rules and that it is under control. The objective of our work is to analyze data from the initial validation and continuous verification of an industrial process for manufacturing film-coated tablets. For this, we used several tools such as risk analysis via the FMECA method and the Ishikawa or 5M diagram, the development of control charts and the process capability study. We applied these analysis techniques on data from 3 consecutive validation batches, as stipulated by GMP. For the analysis of the risks relating to the process, we took into account the steps of wet granulation, compression and film coating. The analysis of the risks relating to the product was limited to the compression and film-coating stages. The control cards concerned the following quality attributes: average mass, hardness, thickness.