Etude expérimentale et prédiction de la solubilité de loratadin avec le modèle NRTL-Sac etude experimental et prediction de la solibilité

Abstract

In this study, the solubility of loratadine, a second-generation antihistamine, was experimentally determined in eight solvents: ethyl acetate, ethanol, 1-propanol, 2-propanol, 1-butanol, dimethylformamide (DMF), acetone, and acetonitrile. Measurements were performed at temperatures (298 K/303 K/308 K) using UV-Vis spectrophotometry. Since experimental solubility studies are costly in terms of time and product, the NRTL-SAC model was used to predict this parameter. The experimental results, along with the thermodynamic properties ΔHfus and Tfus determined by DSC, served as baseline data for predicting loratadine solubility at different temperatures. Comparison of experimental, predicted, and literature results shows good agreement, confirming the reliability of the model. Among the solvents tested, 1-butanol showed the best solubility, followed by 2-propanol and DMF, while acetonitrile exhibited the lowest solubility. These results provide valuable insights into the choice of solvents in pharmaceutical formulations aimed at optimizing the bioavailability of loratadine.