OPTIMIZATION AND FORMULATION OF PHARMACEUTICAL PRODUCTS FOR HEMORRHOIDS THERAPY

Abstract

The purpose of this research is to create a micro-emulgel and suppositories to cure hemorrhoids with natural ingredients like chicken bile and the Teucrium polium extracts. Because ethanol maceration is a straightforward and economical method, we first used it to extract the bioactive components. While several ratios were attempted to identify the ideal extraction conditions for chicken bile, Teucrium polium extraction was optimized using a Box-Behnken design. The main response variables chosen were the total phenolic compounds and the extraction yield. The biological activities of Teucrium polium and chicken bile extracts were assessed after optimization, with an emphasis on their anti-inflammatory, antibacterial, and antioxidant abilities. These results led us to devise a formulation technique. In order to improve the suppository formulation, several excipient ratios were tried, and the best combination was eventually found. An ideal formulation of the microemulgel was achieved by optimizing spreadability and viscosity by the use of a mixture. lattice design.